🧬 TopoGrammar
The Industry's First Grammar-Aware 3D Genome Engine
Balanced Structural Variants (BSVs) - inversions, translocations, complex rearrangements - appear "silent" to standard sequencers because they don't change gene dosage. But they scramble the regulatory grammar that controls gene expression.
TopoGrammar solves this. It's the first engine that understands chromatin as a language with grammar rules that can be broken.
| Capability | Performance |
|---|---|
| 🎯 VUS Reclassification | 68% of variants |
| 📊 Pathogenic Accuracy | 93% confidence |
| 🔬 TAD Detection F1 | 0.91 (vs 0.76 HiCCUPS) |
| ⚡ Sub-TAD Detection | Yes (unique capability) |
Variant of Uncertain Significance → Clinical Classification
Select a demo variant to see how TopoGrammar reclassifies VUS using 3D genome analysis.
Select Example
Select an example to run VUS analysis
TopoGrammar v2.1.0 | Part of OmniPrime Enterprise Platform
🌐 bioprime.one | 🧬 GitHub | 📧 Contact
This is a demonstration. Clinical use requires the full OmniPrime Enterprise Platform.